The State of Intestinal Digestion in Patients with Complicated Peptic Ulcer Disease

Abstract

From a modern standpoint, peptic ulcer disease is considered by most authors as a heterogeneous disease with a multifactorial etiology, complex pathogenesis, chronic recurrent course, occurring with the involvement of other digestive organs in the pathological process. In this regard, the progression of peptic ulcer disease, the development of complications is realized not without the participation of other organs and systems. In practical medicine, the function of the small intestine in patients with complicated peptic ulcer disease often remains outside the attention of doctors. At the same time, the involvement of the small intestine in the pathological process leads to disruption of various types of metabolism, trophic, immunological and regulatory processes in the body of patients, weight loss, the appearance of concomitant pathological conditions. This contributes to a change in clinical symptoms, further progression of gastroduodenal pathology, deterioration in the effectiveness of treatment of patients, creating a "vicious circle with a constant change of cause-and-effect relationships". In this regard, it seems relevant to conduct an in-depth and comprehensive study of the state of the small intestine, as well as the mechanisms of formation of concomitant “enteric” symptoms in complicated duodenal ulcers.