Evaluation of Drug-Related Clinical and Biochemical Parameters in Surgical Management of Primary Open-Angle Glaucoma

Abstract

Despite the abundance of various methods of treating glaucoma, including medication, laser, and surgical treatment of glaucoma provides a significant and lasting reduction in intraocular pressure (IOP) and is therefore considered the most effective. In the late stages of the disease, surgery is the only way to preserve visual functions or stop their deterioration Traditional glaucoma surgery methods include sinus trabeculectomy. Frequent intraocular pressure fluctuations during surgery, due to emptying of the anterior chamber, naturally lead to complications such as ciliochoroidal detachment, iritis, hyphema, cyclocrystalline block, and the development and progression of cataracts Currently, activation of lipid peroxidation (LPO) is considered a universal pathogenetic mechanism underlying the development of a number of pathologies. Hypoxic conditions of various origins, including surgical interventions, are considered to be one of the causes of LPO activation. These conditions reduce the effectiveness of the enzymatic antioxidant defense of the body's cells and, consequently, lead to local or generalized activation of lipid peroxidation. From all of the above, it follows that there is a need to improve surgical methods for the treatment of glaucoma, using drugs that help reduce the intensity of free radical and peroxidation of biomolecules in the body's cells and thus allow for a reduction in the number of intra- and postoperative complications during sinus trabeculectomy (STEC) in advanced stages of primary open-angle glaucoma. The aim of the study: a clinical and laboratory study of lipid peroxidation parameters in the blood plasma of patients in the postoperative period and the antioxidant activity to develop a method for the surgical treatment of uncompensated primary open-angle glaucoma with the introduction of this drug into the anterior chamber of the eye.